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成都先导

打造国际领先的创新型生物医药企业     贡献于更好的人类生命健康

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  2. 发表文章

发表文章

  • 04 一月 2026
    A Mild Intramolecular Cyclization for the Synthesis of N–O Heterocycles and Unlocked Nucleic Acid Analogs
  • 28 十月 2025
    Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry
    ACS Omega 10.1021/acsomega.5c09358
  • 19 四月 2024
    The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
    Bioorganic & Medicinal Chemistry Letters 10.1016/j.bmcl.2024.129675
  • 26 四月 2023
    Carbohydrate−DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates
    Org Lett. 10.1021/acs.orglett.3c00833
  • 14 三月 2023
    Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
    Nucleic Acids Res. https://doi.org/10.1093/nar/gkac173
  • 06 一月 2023
    Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach
    ACS Chem Biol. 10.1021/acschembio.2c00797
  • 26 八月 2022
    PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery
    RSC Med. Chem. 10.1039/d2md00197g
  • 11 四月 2022
    Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
    Frontiers in Chemistry 10.3389/fchem.2022.851674
  • 01 四月 2022
    Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis
    Organic Letters 2022 24 (14), 2650-2654 DOI: 10.1021/acs.orglett.2c00697
  • 24 八月 2021
    A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors
    ACS Omega:A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for https://doi.org/10.1021/acsomega.1c03613

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