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Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization 发布时间:2020-01-30

摘要:


2-Aminobenzimidazole cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. Herein, we report a mild protocol for the synthesis of multifunctional 2-aminobenzimidazoles on-DNA with broad substrate scopes. The reaction conditions expand our ability to design and synthesize 2-aminobenzimidazole core-focused DNA-encoded libraries.



Org. Lett. 2020, 22, 4, 1290–1294

https://doi.org/10.1021/acs.orglett.9b04578

Link:https://pubs.acs.org/doi/10.1021/acs.orglett.9b04578


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