打造国际领先的创新型生物医药企业 贡献于更好的人类生命健康
摘要：
The on-DNA synthesis of highly substituted cyclobutanes was achieved through a photocatalytic [2 + 2] cycloaddition reaction in aqueous solution. Readily available DNA-tagged styrene derivatives were reacted with structurally diverse cinnamates in the presence of an iridium-based photocatalyst, Ir(ppy)2(dtbbpy)PF6, to forge two new C(sp3)–C(sp3) bonds. This transformation was demonstrated to have excellent functional group tolerance and allowed for the facile installation of a variety of heteroaromatic substituents on a densely functionalized cyclobutane scaffold.
Org. Lett. 2020, 22, 8, 2908–2913
https://doi.org/10.1021/acs.orglett.0c00574
Link：https://pubs.acs.org/doi/10.1021/acs.orglett.0c00574
川公网安备 51012202000492号